反应详情

K2CO3 (31.6 g, 223 mmol, 2.23 equiv) and iodoethane (17.8 ml, 230 mmol, 2.3 equiv) were added to a solution of 5-hydroxy-isophthalic acid dimethyl ester (D42) (21 g, 100 mmol, 1 equiv) in acetone (500 ml) at room temperature. The resulting solution was refluxed for 16 h, then cooled to room temperature and concentrated in vacuo. The residue was partitioned between H2O and AcOEt. The aqueous phase was extracted with AcOEt and the combined organic layers were washed with 2N aqueous NaOH solution and brine, dried over MgSO4 and concentrated in vacuo to give 5-ethoxy-isophthalic acid dimethyl ester (D43) (23 g, 96%) as a white solid. RT=3.13 min

1. temperatureThe resulting solution was refluxed for 16 h
2. concentrationconcentrated in vacuo
3. customThe residue was partitioned between H2O and AcOEt
4. extractionThe aqueous phase was extracted with AcOEt
5. washthe combined organic layers were washed with 2N aqueous NaOH solution and brine
6. dry with materialdried over MgSO4
7. concentrationconcentrated in vacuo