Tetrahydrofuran → HCID 58929558, compound

HRID 852766Notes

Reaction equation

HRID 852766 reaction equation
C([NH:9][C:10]([NH:12][C@H:13]1[CH2:18][C@H:17]2[CH2:19][C@@H:14]1[CH2:15][C:16]2([F:21])[F:20])=[S:11])(=O)C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+].O1CCCC1>CO.O>[F:21][C:16]1([F:20])[CH2:15][C@H:14]2[CH2:19][C@@H:17]1[CH2:18][C@@H:13]2[NH:12][C:10]([NH2:9])=[S:11]

Participants

6

Reactant 3

HCID 8028TetrahydrofuranHCID 11430Potassium CarbonateHCID 58929843HCID 58929843, compound

Product 1

HCID 58929558HCID 58929558, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A mixture of 1-benzoyl-3-((1R,2S,4R)-5,5-difluorobicyclo-[2.2.1]heptan-2-yl)thiourea (˜1.80 mmol) and potassium carbonate (1.49 g, 10.8 mmol) in methanol (5.0 mL), water (2.5 mL), and tetrahydrofuran (2.5 mL) was stirred at ambient temperature for 2 h. The reaction mixture was concentrated in vacuo, and the residue was partitioned between EtOAc and water. The organic portion was washed with brine, conc. in vacuo, and purified by flash column chromatography (0 to 65% of ethyl acetate in hexanes) to give the title compound as a white solid. MS m/z: 207.0 (M+H)+.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe residue was partitioned between EtOAc and water
  3. washThe organic portion was washed with brine, conc. in vacuo
  4. custompurified by flash column chromatography (0 to 65% of ethyl acetate in hexanes)

Sources & evidence

ORD record
ord-0766d3c42aa0422a8e952fdb080c776d
Source dataset
uspto-grants-2007_08
Patent number
US07253196B2

Reaction notes

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