反应详情

A suspension of lithium aluminum hydride (263 mg, 6.92 mmol) in THF (20 mL) was added slowly to [1-(methoxy-methyl-carbamoyl)-2-(1-trityl-1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester (3.4 g, 6.3 mmol) in THF (75 mL) at −20° C. The reaction was complete (silica gel, EA, Rf 0.48) in 15 minutes. Saturated sodium potassium tartrate (10 mL) was added, and the solvent removed. Water was added and the residue extracted with Et2O. The Et2O was washed with brine, dried and filtered. Removal of the solvent gave the title compound (2.552 g, 84%). ESMS 482 (M+H+) 1H NMR ( ) 13C NMR ( )

1. customin 15 minutes
2. customthe solvent removed
3. additionWater was added
4. extractionthe residue extracted with Et2O
5. washThe Et2O was washed with brine
6. customdried
7. filtrationfiltered
8. customRemoval of the solvent