Dimethylformamide → HCID 66621956, compound

HRID 852941Notes

Reaction equation

HRID 852941 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[SH:7].[CH3:8][O:9][C:10](=[O:19])[C:11]1[CH:16]=[CH:15][C:14]([CH2:17]Br)=[CH:13][CH:12]=1.CN([CH:23]=[O:24])C>>[CH3:8][O:9][C:10](=[O:19])[C:11]1[CH:16]=[CH:15][C:14]([CH2:17][S:7][C:2]2[N:3]=[C:4]([C:11]3[CH:16]=[CH:15][C:14]([O:24][CH3:23])=[CH:13][CH:12]=3)[CH:5]=[CH:6][N:1]=2)=[CH:13][CH:12]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 256687Methyl 4-(bromomethyl)benzoateHCID 178418793HCID 178418793, compound

Product 1

HCID 66621956HCID 66621956, compound

Conditions

Temperature
60 °C

Procedure

To a solution of 444-methoxy-phenyl)-pyrimidine-2-thiol (225a) (1.00 g, 4.58 mmol) in DMF (30 mL) was added 4-bromomethyl-benzoic acid methyl ester (1.05 g, 4.58 mmol). The mixture was heated at 60° C. for 1 h and evaporated to dryness to form the compound 226a, which was used in the next without purification. LRMS=366.4(calc.), 367.4 (found).

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-53fe78ff2fd94ab9ab4dca6d422165d4
Source dataset
uspto-grants-2007_08
Patent number
US07253204B2

Reaction notes

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