反应详情

To the suspension of 2-[2-(2-Ethoxy-phenyl)-ethylamino]-5-[1-(4-ethoxy-quinolin-6-yl)-meth-(Z)-ylidene]-thiazol-4-one (60 mg, 0.13 mmol) in ethanol (2 mL) was added methanesulfonic acid (9.6 uL, 0.14 mmol) in ethanol (1 mL). After stirring for 30 min, t-butyl methyl ether (5 mL) was added slowly. The mixture was stirred for 3 hours. The solid was collected by filtration and washed with t-butyl methyl ether and dried to give 2-[2-(2-Ethoxy-phenyl)-ethylamino]-5-[1-(4-ethoxy-quinolin-6-yl)-meth-(Z)-ylidene]-thiazol-4-one; compound with methanesulfonic acid as light yellow solid (66 mg, 91%). LC-MS m/e 448 (MH+).

1. stirringThe mixture was stirred for 3 hours
2. filtrationThe solid was collected by filtration
3. washwashed with t-butyl methyl ether
4. customdried