Hydrochloric Acid → HCID 68889040, compound

HRID 853099Notes

Reaction equation

HRID 853099 reaction equation
C(OC([N:8]1[CH2:22][C@@H:21]([CH3:23])[N:11]2[C:12]3[CH:13]=[C:14]([CH3:20])[C:15]([Br:19])=[CH:16][C:17]=3[CH:18]=[C:10]2[CH2:9]1)=O)(C)(C)C.[ClH:24]>C(OCC)(=O)C>[ClH:24].[Br:19][C:15]1[C:14]([CH3:20])=[CH:13][C:12]2[N:11]3[C@H:21]([CH3:23])[CH2:22][NH:8][CH2:9][C:10]3=[CH:18][C:17]=2[CH:16]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68890591HCID 68890591, compound

Product 1

HCID 68889040HCID 68889040, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 0.12 g (R)-8-bromo-4,7-dimethyl-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole-2-carboxylic acid tert-butyl ester in 3 ml of a 2M solution of hydrochloric acid in ethyl acetate was stirred at room temperature under argon for 2 h. The precipitate was collected by filtration and dried to constant weight to yield the title compound (0.065 g) as off-white crystals. m.p.: 241° C. (dec.); ISP-MS: M+H=279.1; HNMR: (250 MHz, DMSO-d6, δ [ppm]) 1.50 (d, J=6.5 Hz, 3H); 2.45 (s, 3H); 3.48–3.74 (m, 2H); 4.36–4.58 (m, 2H); 4.74–4.89 (m, 1H); 6.35 (s, 1H); 7.54 (s, 1H); 7.78 (s, 1H)

Workup

  1. filtrationThe precipitate was collected by filtration
  2. customdried to constant weight

Sources & evidence

ORD record
ord-6bdca8e9717444578b6850e5b013a187
Source dataset
uspto-grants-2007_08
Patent number
US07253281B2

Reaction notes

Loading…