HCID 86603207, compound → HCID 86603206, compound

HRID 853202Notes

Reaction equation

HRID 853202 reaction equation
C(OC([NH:8][CH2:9][CH:10]([S:20][C:21](=[S:37])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])[CH2:11][NH:12]C(OC(C)(C)C)=O)=O)(C)(C)C>CCOCC.Cl>[NH2:12][CH2:11][CH:10]([S:20][C:21](=[S:37])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])[CH2:9][NH2:8]

Participants

4

Reactant 1

HCID 86603207HCID 86603207, compound

Product 1

HCID 86603206HCID 86603206, compoundYield 59%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 3283Diethyl EtherSolvent

Procedure

1,3-[di(tert-butoxycarbonylamino)]-2-tetradecylthioacetylthiopropane (example 15d) (0.300 g, 0.52 mmol) was dissolved in ether saturated in gaseous hydrochloric acid (55 ml). The mixture was stirred at room temperature. After 96 hours of reaction, the precipitate which formed was filtered, washed several times with diethyl ether and dried to give the desired compound in the form of a white powder.

Workup

  1. customAfter 96 hours of reaction
  2. customthe precipitate which formed
  3. filtrationwas filtered
  4. washwashed several times with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-215f27c403674fc8b62b70f3c4a07980
Source dataset
uspto-grants-2007_08
Patent number
US07253296B2

Reaction notes

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