反应详情

N1-Cyclopropyl-5-({2-[di(cyclopropylcarbonyl)amino]-4-pyridyl}oxy)-1H-1-indolecarboxamide (190 mg), ammoniumchloride (660 mg), dimethylformamide (5 ml), water (5 ml) and ethanol (5 ml) were stirred at 100° C. for 1 hour. Water and ethyl acetate were added for extraction, and the extract was washed 6 times with water. After drying over magnesium sulfate, the drying agent was filtered off and the solvent was distilled off under reduced pressure. Ethyl acetate was added to the residue and the precipitated solid was filtered out to obtain 66 mg of a white powder.

1. washthe extract was washed 6 times with water
2. dry with materialAfter drying over magnesium sulfate
3. filtrationthe drying agent was filtered off
4. distillationthe solvent was distilled off under reduced pressure
5. additionEthyl acetate was added to the residue
6. filtrationthe precipitated solid was filtered out