反应详情

4-(5-Aminothiophen-2-ylsulfanyl)-7-methoxyquinoline-6-carboxamide (49.0 mg, 0.150 mmol) and phenylisocyanate (19.6 mg, 0.165 mmol) were stirred in dimethylformamide (1 ml) at room temperature for 2 hours. The reaction solution was distributed between ethyl acetate and water, the organic layer was washed with water and saturated brine and dried over anhydrous magnesium sulfate, the drying agent was filtered off and the filtrate was distilled off under reduced pressure. The obtained crude product was suspended in ethyl acetate and diluted with hexane, and then the crystals were filtered out, washed with hexane and blow-dried to obtain the title compound (25.0 mg, 0.056 mmol, 37%) as light yellow crystals.

1. washthe organic layer was washed with water and saturated brine
2. dry with materialdried over anhydrous magnesium sulfate
3. filtrationthe drying agent was filtered off
4. distillationthe filtrate was distilled off under reduced pressure
5. customThe obtained crude product
6. filtrationthe crystals were filtered out
7. washwashed with hexane
8. customblow-dried