反应详情

4-Chloro-2-[(cyclopropylmethyl)aminocarbonyl]pyridine (1.5 g), p-nitrophenol (2.0 g), Hunig's base (3.1 ml) and 1-methyl-2-pyrrolidinone (6.2 ml) were stirred together at 160° C. for 3 hours. Water was added, extraction was performed with ethyl acetate, and the solvent was distilled off under reduced pressure. The residue was purified by column chromatography (hexane:ethyl acetate=4:1, followed by 2:1) using NH type silica gel to obtain 0.35 g of the target substance as a colorless oil.

1. extractionextraction
2. distillationthe solvent was distilled off under reduced pressure
3. customThe residue was purified by column chromatography (hexane:ethyl acetate=4:1, followed by 2:1)
4. customto obtain 0.35 g of the target substance as a colorless oil