Dimethylformamide → HCID 22936876, compound

HRID 853552Notes

Reaction equation

HRID 853552 reaction equation
C1([O:7][C:8](=O)[NH:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]3[C:26]4[C:21](=[CH:22][C:23]([O:29][CH2:30][C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=5)=[C:24]([C:27]#[N:28])[CH:25]=4)[N:20]=[CH:19][CH:18]=3)=[CH:12][C:11]=2[Cl:37])C=CC=CC=1.[CH3:39][N:40](C)C=O.O1CCCC1>O>[CH2:30]([O:29][C:23]1[CH:22]=[C:21]2[C:26]([C:17]([O:16][C:13]3[CH:14]=[CH:15][C:10]([NH:9][C:8]([NH:40][CH3:39])=[O:7])=[C:11]([Cl:37])[CH:12]=3)=[CH:18][CH:19]=[N:20]2)=[CH:25][C:24]=1[C:27]#[N:28])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 67204096HCID 67204096, compound

Product 1

HCID 22936876HCID 22936876, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

[4-(7-Benzyloxy-6-cyanoquinolin-4-yloxy)-2-chloro phenyl]carbamic acid phenyl ester (1.17 g) was added to dimethylformamide (6 ml), and then amethylamine-containing 2N tetrahydrofuran solution (0.4 ml) was added and the mixture was stirred for 10 minutes. Water (15 ml) was added, and the precipitated crystals were filtered out and washed with diethyl ether to obtain the title compound (968 mg)

Workup

  1. additionwas added
  2. filtrationthe precipitated crystals were filtered out
  3. washwashed with diethyl ether

Sources & evidence

ORD record
ord-750866bf36194eef8c4fc0349b4d4eb1
Source dataset
uspto-grants-2007_08
Patent number
US07253286B2

Reaction notes

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