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7-[2-(4-Fluoro-phenyl)-ethyl]-5,9-dihydroxy-pyrrolo[3,4-g]quinoline-6,8-dione 310 (250 mg, 0.71 mmol).was dissolved in dioxane (3.6 ml) and H2O (2.4 ml) and cooled to 0° C. After 1.0 M NaOH (1.42 ml, 1.42 mmol) and ethylchloroformate (84.6 mg, 0.78 mmol) were added, the reaction was stirred at 0° C. for one hour. The reaction mixture was quenched with the addition of acetic acid (0.6 ml) and concentrated in vacuo. The crude mixture was diluted with ethyl acetate and washed once with 5% Citric Acid (aqueous), twice with water, once with brine, dried over magnesium sulfate, and concentrated in vacuo. The resulting residue was dissolved in 1,2-dichloroethane (4.0 ml) and to this was added diphenyl-methanediazonium 38 (252 mg, 1.3 mmol). The reaction mixture was then stirred overnight at room temperature. Following dilution with dichloromethane, the reaction mixture was washed with once with water, once with brine, dried over magnesium sulfate, and concentrated in vacuo. The residue was then purified by silica gel chromatography (1/1—hexane/ethyl acetate) to afford carbonic acid 9-benzhydryloxy-7-[2-(4-fluoro-phenyl)-ethyl]-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester ethyl ester 311 (251 mg, 0.425 mmol, 65%). 1H NMR (d-DMSO) δ 9.19 (dd, 1H), 8.52 (dd, 1H), 7.90 (s, 1H), 7.80 (m, 1H), 7.54 (m, 4H), 7.20 (m, 8H), 7.02 (t, 2H), 4.24 (q, 2H), 3.79 (t, 2H), 2.90 (t, 2H), 1.25 (t, 3H). MS: 599.2 (M+23).

1. customThe reaction mixture was quenched with the addition of acetic acid (0.6 ml)
2. concentrationconcentrated in vacuo
3. additionThe crude mixture was diluted with ethyl acetate
4. washwashed once with 5% Citric Acid (aqueous), twice with water, once with brine
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated in vacuo
7. dissolutionThe resulting residue was dissolved in 1,2-dichloroethane (4.0 ml)
8. stirringThe reaction mixture was then stirred overnight at room temperature
9. washthe reaction mixture was washed with once with water
10. dry with materialonce with brine, dried over magnesium sulfate
11. concentrationconcentrated in vacuo
12. customThe residue was then purified by silica gel chromatography (1/1—hexane/ethyl acetate)