3-Hydroxybenzaldehyde → HCID 69516964, compound

HRID 853816Notes

Reaction equation

[O:1]=[C:2]1[NH:6][CH2:5][C:4](=[O:7])[N:3]1[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([C:18]#[N:19])=[CH:10][CH:9]=1.[OH:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH:24]=O>>[OH:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH:24]=[C:5]1[C:4](=[O:7])[N:3]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([C:18]#[N:19])=[CH:10][CH:9]=2)[C:2](=[O:1])[NH:6]1

Participants

Reactant 2

HCID 1013-Hydroxybenzaldehyde

HCID 58932670HCID 58932670, compound

Product 1

HCID 69516964HCID 69516964, compound

Procedure

The title compound was obtained as an off-white solid (38.5 mg, 18.2%) from compound 1C and 3-hydroxybenzaldehyde in the same manner as that used in the preparation of Example 1 by acidifying the aqueous washings and recrystallization of the crude product from MeOH. LC/MS m/z 356 [M+H]+.

Sources & evidence

ORD record: ord-34d89c5378634a68a915d813cab87d79
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07256208B2

Reaction notes

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