4-Hydroxybenzaldehyde → HCID 69516270, compound

HRID 853817Notes

Reaction equation

[O:1]=[C:2]1[NH:6][CH2:5][C:4](=[O:7])[N:3]1[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([C:18]#[N:19])=[CH:10][CH:9]=1.[OH:20][C:21]1[CH:28]=[CH:27][C:24]([CH:25]=O)=[CH:23][CH:22]=1>>[OH:20][C:21]1[CH:28]=[CH:27][C:24]([CH:25]=[C:5]2[C:4](=[O:7])[N:3]([C:8]3[C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[C:11]([C:18]#[N:19])=[CH:10][CH:9]=3)[C:2](=[O:1])[NH:6]2)=[CH:23][CH:22]=1

Participants

Reactant 2

HCID 1264-Hydroxybenzaldehyde

HCID 58932670HCID 58932670, compound

Product 1

HCID 69516270HCID 69516270, compound

Procedure

The title compound was obtained as an off-white solid (37.3 mg, 17.6%), mp>275° C. from compound 1C and 4-hydroxybenzaldehyde in the same manner as that used in the preparation of Example 1 by acidifying the aqueous washings and recrystallization of the crude product from MeOH. LC/MS m/z 356 [M+H]+.

Sources & evidence

ORD record: ord-6df4a666734349d39a2d6b2a41ee5c98
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07256208B2

Reaction notes

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