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温度

0 °C

Under atmosphere of argon, a solution of (4S)-4-(hydroxymethyl)-1,3-oxazolidine-2-one (34.1 g) in N,N-dimethylformamide (300 mL) was added by imidazole (25.7 g) and was cooled down to the temperature of 0° C. To the mixture, a solution of tert-butyldimethylsilylchloride (48.2 g) in N,N-dimethylformamide (300 mL) was moderately dropped and the mixture was stirred overnight at room temperature. The mixture was diluted with ethyl acetate and water and was washed with saturated brine. The organic layer was dried over an anhydrous magnesium sulfate and concentrated to give the title compound (64.8 g) having the following physical data, which was used for the next reaction without purification.

1. washwas washed with saturated brine
2. dry with materialThe organic layer was dried over an anhydrous magnesium sulfate
3. concentrationconcentrated