3-Methylbenzaldehyde → HCID 90723180, compound

HRID 853938Notes

Reaction equation

HRID 853938 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH:7]=[CH:6][C:5]=1[O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[O:3].[C:22]1([CH3:30])[CH:27]=[CH:26][CH:25]=[C:24]([CH:28]=O)[CH:23]=1>>[F:21][C:18]([F:19])([F:20])[CH2:17][O:16][C:5]1[CH:6]=[CH:7][C:8]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])=[CH:9][C:4]=1[C:2](=[O:3])[CH:1]=[CH:30][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[CH:23]=1

Participants

3

Reactant 2

HCID 121053-MethylbenzaldehydeHCID 27360731-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-one

Product 1

HCID 90723180HCID 90723180, compound

Procedure

The title compound was prepared from a mixture of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone (200 mg, 0.633 mmol) and m-tolualdehyde (75 ul, 0.633 mmol) similar to Example 6 and isolated as a pale yellow solid (76.2 mg, 29%). 1H NMR (CDCl3): 7.66 (d, J=15.9 Hz, 1H), 7.44 (d, J=15.6 Hz, 1H), 7.42-7.38 (m, 2H), 7.31-7.20 (m, 3H), 7.10 (dd, J=3.2, 8.9 Hz, 1H), 6.93 (d, J=9.0 Hz, 1H), 4.43-4.32 (m, 4H), 2.37 (s, 3H).

Sources & evidence

ORD record
ord-a0943b78774248f4b67845c5170619ba
Source dataset
uspto-grants-2007_08
Patent number
US07256219B2

Reaction notes

Loading…