2-Pyridinecarboxaldehyde → HCID 85331303, compound

HRID 853941Notes

Reaction equation

HRID 853941 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH:7]=[CH:6][C:5]=1[O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[O:3].[N:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[CH:28]=O>>[F:21][C:18]([F:19])([F:20])[CH2:17][O:16][C:5]1[CH:6]=[CH:7][C:8]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])=[CH:9][C:4]=1[C:2](=[O:3])[CH:1]=[CH:28][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][N:22]=1

Participants

3

Reactant 2

HCID 142732-PyridinecarboxaldehydeHCID 27360731-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-one

Product 1

HCID 85331303HCID 85331303, compound

Procedure

The title compound was prepared from a mixture of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone (100 mg, 0.316 mmol) and 2-pyridine carboxaldehyde (30 ul, 0.316 mmol) similar to Example 15 and isolated as a yellow solid (13 mg, 10%) 1H NMR (CDCl3): 8.68-8.65 (m, 1H), 7.79 (d, J=15.6 Hz, 1H), 7.72 (dd, J=1.7, 7.7 Hz, 1H), 7.64 (d, J=15.6 Hz, 1H), 7.53 (d, J=7.8 Hz, 1H), 7.31-7.28 (m, 1H), 7.25 (s, 1H), 7.12 (dd, J=3.2, 8.9 Hz, 1H), 6.96 (d, J=9.3 Hz, 1H), 4.44-4.33 (m, 4H).

Sources & evidence

ORD record
ord-6314e6dc117b42dba1c35639ca12a67c
Source dataset
uspto-grants-2007_08
Patent number
US07256219B2

Reaction notes

Loading…