反应详情

2-(N-benzylamino)methyl-6-methoxytetralin hydrochloride (0.602 g; obtained in Reference Example 6), 3,3-diphenylpropyl iodide (0.803 g) and potassium carbonate (0.800 g) were added to DMF (20 ml). The reaction mixture was stirred at room temperature for 24 hours, and water was added thereto, which was then extracted with ethyl acetate. The organic layer was washed with water and a saturated aqueous sodium chloride solution, then dried, and concentrated. The residue was purified by silica gel column chromatography (eluent:ethyl acetate/hexane=1/1) to obtain the entitled compound (0.335 g).

1. extractionwhich was then extracted with ethyl acetate
2. washThe organic layer was washed with water
3. dry with materiala saturated aqueous sodium chloride solution, then dried
4. concentrationconcentrated
5. customThe residue was purified by silica gel column chromatography (eluent:ethyl acetate/hexane=1/1)