HCID 22998584, compound → HCID 22998664, compound

HRID 854031Notes

Reaction equation

HRID 854031 reaction equation
[ClH:1].Cl.[CH2:3]([N:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[C:22]([O:27]C)[CH:23]=3)[CH2:18]2)[CH2:12][CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>Cl>[ClH:1].[ClH:1].[CH2:3]([N:10]1[CH2:11][CH2:12][N:13]([CH2:16][CH:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[C:22]([OH:27])[CH:23]=3)[CH2:18]2)[CH2:14][CH2:15]1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 1

HCID 22998584HCID 22998584, compound

Product 1

HCID 22998664HCID 22998664, compoundYield 127.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-(4-Benzylpiperazin-1-yl)methyl-6-methoxytetralin dihydrochloride (0.849 g) was added to conc. hydrochloric acid (20 ml) and the reaction mixture was heated under reflux for 6 hr and cooled. The resulting precipitate was collected and washed with ethanol, methanol, and diethyl ether to obtain the titled compound (0.523 g).

Workup

  1. temperaturethe reaction mixture was heated
  2. temperatureunder reflux for 6 hr
  3. temperaturecooled
  4. customThe resulting precipitate was collected
  5. washwashed with ethanol, methanol, and diethyl ether

Sources & evidence

ORD record
ord-867f7d332a254144b2c27a2b0ab1bad2
Source dataset
uspto-grants-2007_08
Patent number
US07256204B2

Reaction notes

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