反应详情

A solution of 100 mg (0.25 mmol) of N-(1-azabicyclo[2.2.2]oct-3-yl)-4-iodo-3-nitrobenzamide and 281 mg (1.25 mmol) of tin(II) chloride dihydrate in 5 ml of DMF was stirred at room temperature for 6 h. The solvent was distilled off in a rotary evaporator, the residue was taken up in 10 ml of dichloromethane, and 10 ml of aqueous 1 M sodium hydroxide solution were added. The organic phase was dried over sodium sulfate, and the solvent was distilled off in a rotary evaporator. 91 mg (98%) of the desired title compound were obtained.

1. distillationThe solvent was distilled off in a rotary evaporator
2. addition10 ml of aqueous 1 M sodium hydroxide solution were added
3. dry with materialThe organic phase was dried over sodium sulfate
4. distillationthe solvent was distilled off in a rotary evaporator