Potassium Carbonate → HCID 15546708, compound

HRID 854250Notes

Reaction equation

HRID 854250 reaction equation
[Cl:1][C:2]1[C:3]2[CH:11]=[CH:10][NH:9][C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:18]([O:20][C:21](=[O:26])[CH2:22][CH2:23][CH2:24]Br)[CH3:19]>CN(C=O)C>[CH2:18]([O:20][C:21](=[O:26])[CH2:22][CH2:23][CH2:24][N:9]1[C:4]2[N:5]=[C:6]([CH3:8])[N:7]=[C:2]([Cl:1])[C:3]=2[CH:11]=[CH:10]1)[CH3:19]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 76300Ethyl 4-bromobutyrateHCID 109208984-CHLORO-2-METHYL-7H-PYRROLO[2,3-D]PYRIMIDINE

Product 1

HCID 15546708HCID 15546708, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

0.5 g (3 mmol) of 4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine (prepared according to West and Beauchamp, J. Org. Chem. 26 (1961) 3809) was dissolved in 3 ml DMF and 2.06 g (15 mmol) of potassium carbonate was added to this solution. 0.431 ml (3 mmol) of 4-bromobutyric acid ethyl ester was added and the mixture was stirred at 50° C. for 45 minutes. The reaction mixture was diluted with 50 ml EE and washed three times with water, dried over MgSO4, filtered and the solvent was removed in vacuo. Yield: 0.8 g.

Workup

  1. additionThe reaction mixture was diluted with 50 ml EE
  2. washwashed three times with water
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-3b046e1d6b994a2b81a9222878e57b4d
Source dataset
uspto-grants-2007_08
Patent number
US07259159B2

Reaction notes

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