Trifluoroacetic acid → HCID 15547260, compound

HRID 854258Notes

Reaction equation

HRID 854258 reaction equation
C(O)(C(F)(F)F)=O.C([O:12][C:13](=[O:50])[C@@H:14]([NH:39][S:40]([C:43]1[CH:48]=[CH:47][C:46]([Br:49])=[CH:45][CH:44]=1)(=[O:42])=[O:41])[CH2:15][NH:16][C:17]1[C:18]2[CH:26]=[CH:25][N:24]([CH2:27][CH2:28][CH2:29][C:30](=[O:38])[NH:31][C:32]3[NH:33][CH2:34][CH2:35][CH2:36][N:37]=3)[C:19]=2[N:20]=[C:21]([CH3:23])[N:22]=1)(C)(C)C>C(Cl)Cl>[CH3:23][C:21]1[N:22]=[C:17]([NH:16][CH2:15][C@H:14]([NH:39][S:40]([C:43]2[CH:44]=[CH:45][C:46]([Br:49])=[CH:47][CH:48]=2)(=[O:42])=[O:41])[C:13]([OH:50])=[O:12])[C:18]2[CH:26]=[CH:25][N:24]([CH2:27][CH2:28][CH2:29][C:30](=[O:38])[NH:31][C:32]3[NH:33][CH2:34][CH2:35][CH2:36][N:37]=3)[C:19]=2[N:20]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 15546714HCID 15546714, compound

Product 1

HCID 15547260HCID 15547260, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.5 ml of TFA were added to a solution of 70 mg of (2S)-3-(2-methyl-7-[3-(1,4,5,6-tetrahydro-pyrimidin-2-ylcarbamoyl)-propyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-2-(4-bromobenzenesulfonylamino)-propionic acid tert-butyl ester (example 5b) in 5 ml of DCM and stirred for 2 h at room temperature. Solvent and TFA were removed in vacuo, the residue was lyophilized from AcOH/H2O (1:1). Yield: 76 mg.

Workup

  1. customSolvent and TFA were removed in vacuo

Sources & evidence

ORD record
ord-035f5a626d5f4b738fb44d4c3687b5a2
Source dataset
uspto-grants-2007_08
Patent number
US07259159B2

Reaction notes

Loading…