Hydrochloric Acid → HCID 131726552, compound

HRID 854284Notes

Reaction equation

HRID 854284 reaction equation
C(OC([NH:8][C@H:9]([CH2:23][C:24]1[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:25]=1[F:32])[CH2:10][C:11]([N:13]1[CH2:19][CH2:18][C@@H:17]([CH3:20])[NH:16][C:15](=[O:21])[C@H:14]1[CH3:22])=[O:12])=O)(C)(C)C.[ClH:33]>O1CCOCC1>[ClH:33].[NH2:8][C@H:9]([CH2:23][C:24]1[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:25]=1[F:32])[CH2:10][C:11]([N:13]1[CH2:19][CH2:18][C@@H:17]([CH3:20])[NH:16][C:15](=[O:21])[C@H:14]1[CH3:22])=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69156110HCID 69156110, compound

Product 1

HCID 131726552HCID 131726552, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of (3R,7R)-4-[(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]-3,7-dimethyl-1,4-diazepan-2-one (175 mg, 0.38 mmol) in 4 mL of 4N hydrogen chloride in dioxane (4 mL, 4N) was stirred for 2 h and concentrated. The residue was dried under vacuum overnight to yield the title compound as a white solid. MS 358.2 (M+1).

Workup

  1. concentrationconcentrated
  2. customThe residue was dried under vacuum overnight

Sources & evidence

ORD record
ord-75e1798cc571455e86e336cc57dedd1d
Source dataset
uspto-grants-2007_08
Patent number
US07259160B2

Reaction notes

Loading…