反应详情

温度

50 °C

To a solution of 1,4-dibenzyl-2-chloromethyl-piperazine (8.8 g, 0.028 mol) in dimethylformamide (90 mL) under nitrogen was added sodium azide (5.5 g) and the reaction stirred at 50° C. for 18 h. The reaction was cooled and diluted with 10% aqueous sodium bicarbonate (100 mL) and water (250 mL) and the mixture extracted with ethyl acetate (2×200 mL). The organic extracts were washed with 10% sodium bicarbonate, brine, dried over sodium sulfate and concentrated to an oil.

1. temperatureThe reaction was cooled
2. extractionthe mixture extracted with ethyl acetate (2×200 mL)
3. washThe organic extracts were washed with 10% sodium bicarbonate, brine
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated to an oil