Water → Benzyl 4-(aminomethyl)-4-fluoropiperidine-1-carboxylate

HRID 854332Notes

Reaction equation

HRID 854332 reaction equation
[N:1]([CH2:4][C:5]1([F:21])[CH2:10][CH2:9][N:8]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])[CH2:7][CH2:6]1)=[N+]=[N-].O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1COCC1>[NH2:1][CH2:4][C:5]1([F:21])[CH2:6][CH2:7][N:8]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])[CH2:9][CH2:10]1

Participants

5

Reactant 3

HCID 962WaterHCID 11776TriphenylphosphineHCID 22135652Benzyl 4-(azidomethyl)-4-fluoropiperidine-1-carboxylate

Product 1

HCID 22135645Benzyl 4-(aminomethyl)-4-fluoropiperidine-1-carboxylate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of benzyl 4-(azidomethyl)-4-fluoropiperidine-1-carboxylate (1.5 g, 5.1 mmol) in THF (10 mL) at RT with added water (0.92 mL, 0.92 mmol) and triphenylphosphine (4.3 g, 15.4 mmol). The reaction mixture was stirred for 60 h, concentrated, dissolved in HCl (1M) and extracted with Et2O four times. The aqueous layer was basified to pH 11 and extracted with EtOAc twice. The organic layer was dried over Na2SO4, filtered and concentrated. The crude mixture was chromatographed on silica gel (CH2Cl2 to 80:20:2 CH2C12:MeOH:NH4OH) to give benzyl 4-(aminomethyl)-4-fluoropiperidine-1-carboxylate.

Workup

  1. customat RT
  2. concentrationconcentrated
  3. dissolutiondissolved in HCl (1M)
  4. extractionextracted with Et2O four times
  5. extractionextracted with EtOAc twice
  6. dry with materialThe organic layer was dried over Na2SO4
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customThe crude mixture was chromatographed on silica gel (CH2Cl2 to 80:20:2 CH2C12:MeOH:NH4OH)

Sources & evidence

ORD record
ord-7b0997687f37436ca683f71c251b04b4
Source dataset
uspto-grants-2007_08
Patent number
US07259157B2

Reaction notes

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