Triethylamine → HCID 59016359, compound

HRID 854339Notes

Reaction equation

HRID 854339 reaction equation
Cl.[C:2]([O:6][C:7](=[O:14])[CH:8]([NH2:13])[CH2:9][CH:10]([CH3:12])[CH3:11])([CH3:5])([CH3:4])[CH3:3].[N:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH:21]=O.C(N(CC)CC)C>ClCCl>[N:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH:21]=[N:13][CH:8]([CH2:9][CH:10]([CH3:11])[CH3:12])[C:7]([O:6][C:2]([CH3:3])([CH3:5])[CH3:4])=[O:14]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 142732-PyridinecarboxaldehydeHCID 18326953HCID 18326953, compound

Product 1

HCID 59016359HCID 59016359, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A stirred mixture of 2-amino-4-methylpentanoic acid tert-butyl ester hydrochloride (5.00 g, 22.35 mmol), pyridine-2-carboxaldehyde (2.12 mL, 22.35 mmol) and triethylamine (3.11 mL, 22.35 mmol) in dichloromethane (75 mL) was heated under reflux under nitrogen for 2 hours. The reaction mixture was allowed to cool to room temperature, washed with water and brine, dried over MgSO4 and evaporated to give the title compound as an oil.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux under nitrogen for 2 hours
  3. washwashed with water and brine
  4. dry with materialdried over MgSO4
  5. customevaporated

Sources & evidence

ORD record
ord-7316f60357a94fbe9a0e114cb6f1a9db
Source dataset
uspto-grants-2007_08
Patent number
US07259163B2

Reaction notes

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