Hydrochloric Acid → HCID 69179024, compound

HRID 854439Notes

Reaction equation

HRID 854439 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[N:10]=[CH:11][O:12][C:13]=1[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([C:20]([CH:23]([CH3:25])[CH3:24])=[N:21][N:22]=2)[CH:19]=1.[ClH:26]>C(O)(C)C>[ClH:26].[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[N:10]=[CH:11][O:12][C:13]=1[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([C:20]([CH:23]([CH3:25])[CH3:24])=[N:21][N:22]=2)[CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9949821CP-863187

Product 1

HCID 69179024HCID 69179024, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

Crude 6-[4-(2,5-difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine (5.0 g) was dissolved in isopropanol (40 ml). Hydrochloric acid (13.3% weight) in isopropanol (4.4 g) was added. The resulting slurry was stirred at room temperature for 30 minutes and filtered. The cake was washed with isopropanol and dried in a vacuum oven (80° C.) for 2 hours. 6-[4-(2,5-Difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine hydrogen chloride was obtained as an off-white solid (2.8 g, yield 50%).

Workup

  1. filtrationfiltered
  2. washThe cake was washed with isopropanol
  3. customdried in a vacuum oven (80° C.) for 2 hours

Sources & evidence

ORD record
ord-ff58f57a1f334903b4be2049079d694c
Source dataset
uspto-grants-2007_08
Patent number
US07259171B2

Reaction notes

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