反应详情

A solution of 6,8-Dibromo-imidazo[1,2-a]pyrazine 3 (1.0 equiv.), 4-aminomethylpyridine (1.0 equiv.) and potassium carbonate (3.0 equiv.) is dissolved in 20 ml 3:1 acetonitrile: dimethylacetamide and is stirred at 100° C. for 16 hours. The mixture is cooled to RT and partitioned between ethyl acetate (EtOAc) and saturated NaHCO3. The aqueous phase is extracted with EtOAc and combined extracts are dried over Na2SO4. The solvent is removed under reduced pressure and the resulting residue is purified by flash chromatography (EtOAc) to yield (6-Bromo-imidazo[1,2-a]pyrazin-8-yl)-pyridin-4-ylmethyl-amine 4.

1. custompartitioned between ethyl acetate (EtOAc) and saturated NaHCO3
2. extractionThe aqueous phase is extracted with EtOAc and combined extracts
3. dry with materialare dried over Na2SO4
4. customThe solvent is removed under reduced pressure
5. customthe resulting residue is purified by flash chromatography (EtOAc)