反应详情

To a stirred solution of (3,4-dihydroxybutyl)carbamic acid tert-butyl ester (2.60 g, 12.7 mmol), triethylamine (2.03 mL, 14.50 mmol) and 4-(dimethylamino)pyridine (0.05 g, 0.4 mmol) in anhydrous dichloromethane (40 mL) at room temperature was added tert-butyldimethylchlorosilane (2.0 g, 13.17 mmol) in one portion. The resulting mixture was stirred at room temperature for 18 hours, washed with water, brine and dried over anhydrous magnesium sulfate. Filtration and concentration in vacuo gave an oil which was purified by column chromatography on silica using ethyl acetate—petroleum ether mixture as eluent to afford a colourless oil.

1. washwashed with water, brine
2. dry with materialdried over anhydrous magnesium sulfate
3. filtrationFiltration and concentration in vacuo
4. customgave an oil which
5. customwas purified by column chromatography on silica
6. customto afford a colourless oil