Hydrochloric Acid → HCID 69492514, compound

HRID 855460Notes

Reaction equation

HRID 855460 reaction equation
[CH2:1]([O:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]=[CH:15][C:16]2[CH:38]=[CH:37][C:19]([CH2:20][O:21][CH2:22][CH:23]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[O:24][C@@H]3CCCCO3)=[CH:18][CH:17]=2)=[CH:10][CH:9]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].Cl>C(O)C>[C:31]1([C@@H:23]([OH:24])[CH2:22][O:21][CH2:20][C:19]2[CH:37]=[CH:38][C:16](/[CH:15]=[CH:14]/[C:11]3[CH:10]=[CH:9][C:8]([O:7][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])=[CH:13][CH:12]=3)=[CH:17][CH:18]=2)[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69490685HCID 69490685, compound

Product 1

HCID 69492514HCID 69492514, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.4 g of (R)-2-(2-{4-[2-(4-Hexyloxy-phenyl)-vinyl]-benzyloxy}-1-phenyl-ethoxy)-tetrahydro-pyran (4) were dissolved in 30 ml of ethanol. Hydrochloric acid was added dropwise to obtain an acidic medium. Then the mixture was refluxed for 30 min. Upon cooling the product crystallized. The solid was filtered, washed with ethanol, and dried in a dessicator.

Workup

  1. customto obtain an acidic medium
  2. temperatureThen the mixture was refluxed for 30 min
  3. temperatureUpon cooling the product
  4. customcrystallized
  5. filtrationThe solid was filtered
  6. washwashed with ethanol
  7. customdried in a dessicator

Sources & evidence

ORD record
ord-d8c43d69f3a24429a8b8bed72d8f637d
Source dataset
uspto-grants-2007_08
Patent number
US07261836B2

Reaction notes

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