反应详情

To a stirred solution of 3-bromophenylsulfonyl chloride (5 g, 0.0196 mol) in acetonitrile (20 ml) was added potassium fluoride (2.27 g, 0.0391 mol) followed by 18-crown-6 ether (0.08 g) and the reaction stirred at room temperature for 18 h. The reaction mixture was then washed with water (60 ml), extracted with ethyl acetate (3×80 ml) and the combined organic extracts dried (Na2SO4). Solvents were evaporated in vacuo to give a yellow oil (3.79 g, 81%).

1. washThe reaction mixture was then washed with water (60 ml)
2. extractionextracted with ethyl acetate (3×80 ml)
3. dry with materialthe combined organic extracts dried (Na2SO4)
4. customSolvents were evaporated in vacuo