Sodium Chloride → HCID 69516387, compound

HRID 855527Notes

Reaction equation

HRID 855527 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[O:7]=[S:8]1(=[O:32])[C:13]2[CH:14]=[C:15]([O:18][C:19]3[CH:24]=[CH:23][C:22]([CH:25]([CH3:28])[C:26]#[N:27])=[CH:21][CH:20]=3)[CH:16]=[CH:17][C:12]=2[N:11]2[CH2:29][CH2:30][CH2:31][CH:10]2[NH:9]1.[H-].[Na+].[Cl-]>C1COCC1>[O:32]=[S:8]1(=[O:7])[C:13]2[CH:14]=[C:15]([O:18][C:19]3[CH:24]=[CH:23][C:22]([CH:25]([CH3:28])[CH2:26][NH2:27])=[CH:21][CH:20]=3)[CH:16]=[CH:17][C:12]=2[N:11]2[CH2:29][CH2:30][CH2:31][CH:10]2[NH:9]1

Participants

6

Reactant 4

HCID 5234Sodium ChlorideHCID 166653HydrideHCID 21226445Aluminium lithium hydrideHCID 69516341HCID 69516341, compound

Product 1

HCID 69516387HCID 69516387, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

200 mg (5.25 mmol) of LiAlH4, in small portions, are added to a solution containing 485 mg (1.31 mmol) of the compound of Step A above in 15 ml of THF. After reacting for 3 hours, the excess hydride is hydrolysed by dropwise addition of saturated aqueous NaCl solution. The reaction mixture is filtered, the solid is rinsed several times with THF and the filtrate is evaporated to yield a white meringue corresponding to the title compound.

Workup

  1. filtrationThe reaction mixture is filtered
  2. washthe solid is rinsed several times with THF
  3. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-3a10f9aedfac42209eb89c9403351385
Source dataset
uspto-grants-2007_08
Patent number
US07262190B2

Reaction notes

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