Dimethylamine → HCID 69515484, compound

HRID 855528Notes

Reaction equation

HRID 855528 reaction equation
[CH3:1][NH:2][CH3:3].[O:4]=[S:5]1(=[O:29])[C:10]2[CH:11]=[C:12]([O:15][C:16]3[CH:21]=[CH:20][C:19]([CH2:22][C:23](O)=[O:24])=[CH:18][CH:17]=3)[CH:13]=[CH:14][C:9]=2[N:8]2[CH2:26][CH2:27][CH2:28][CH:7]2[NH:6]1>C1COCC1>[O:4]=[S:5]1(=[O:29])[C:10]2[CH:11]=[C:12]([O:15][C:16]3[CH:17]=[CH:18][C:19]([CH2:22][C:23]([N:2]([CH3:3])[CH3:1])=[O:24])=[CH:20][CH:21]=3)[CH:13]=[CH:14][C:9]=2[N:8]2[CH2:26][CH2:27][CH2:28][CH:7]2[NH:6]1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 69515909HCID 69515909, compound

Product 1

HCID 69515484HCID 69515484, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The procedure is as in Step A of Example 3 but replacing the ammonia gas with 2M dimethylamine in THF and 3-{4-[5,5-dioxo-2,3-dihydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazin-7-yl)oxy]phenyl}propanoic acid by the compound obtained in Step B. Purification is carried out by chromatography on a silica column, eluting with a mixture of CH2Cl2/MeOH 99/1, followed by crystallisation from water.

Workup

  1. customPurification
  2. washeluting with a mixture of CH2Cl2/MeOH 99/1
  3. customfollowed by crystallisation from water

Sources & evidence

ORD record
ord-6636c1819d8c49f09dec171cd1e37a47
Source dataset
uspto-grants-2007_08
Patent number
US07262190B2

Reaction notes

Loading…