Tetrahydrofuran → HCID 178526743, compound

HRID 855665Notes

Reaction equation

HRID 855665 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([Cl:11])[N:5]=[CH:4][N:3]=1.[NH2:12][C:13]1[CH:17]=[CH:16][NH:15][N:14]=1.[CH2:18]1[CH2:22]OC[CH2:19]1>>[Cl:11][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:12][C:13]2[NH:14][N:15]=[C:16]([CH:19]3[CH2:18][CH2:22]3)[CH:17]=2)[C:7]=1[N+:8]([O-:10])=[O:9]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 203124,6-Dichloro-5-nitropyrimidineHCID 178418806HCID 178418806, compound

Product 1

HCID 178526743HCID 178526743, compound

Procedure

To a solution of 4,6-dichloro-5-nitro-pyrimidine (100 mg, 0.52 mmol) in anhydrous THF (2 mL) was added aminopyrazole (76 mg, 0.62 mmol). The solution was stirred at RT for 2 hrs and was filtered via short silica gel column. The filtrate that contained product and the unreacted starting pyrrimidine was concentrated under vacuum. The resulting residue was used directly without further purification.

Workup

  1. filtrationwas filtered via short silica gel column
  2. concentrationwas concentrated under vacuum
  3. customThe resulting residue was used directly without further purification

Sources & evidence

ORD record
ord-eb0861f658c64e0dbed2f7cb1a384254
Source dataset
uspto-grants-2007_08
Patent number
US07262200B2

Reaction notes

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