HCID 21701573, compound → HCID 10681434, compound

HRID 855690Notes

Reaction equation

HRID 855690 reaction equation
Cl.[Cl:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:10][CH:11]=2)[N:6]=[CH:5][N:4]=1>O.C(OCC)(=O)C.C(=O)([O-])O.[Na+]>[Cl:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:10][CH:11]=2)[N:6]=[CH:5][N:4]=1

Participants

5

Reactant 1

HCID 21701573HCID 21701573, compound

Product 1

HCID 10681434HCID 10681434, compoundYield 80.3%

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 8857Ethyl AcetateSolventHCID 516892Sodium BicarbonateSolvent

Procedure

A suspension of 4-chloro-7-(2-methoxyethoxy)quinazoline hydrochloride (500 mg, 1.8 mmol) in a mixture of water (20 ml) and ethyl acetate (20 ml) was diluted with a saturated solution of sodium hydrogen carbonate. After stirring at ambient tempreature for 15 minutes the solution was extracted with ethyl acetate. The organic layer was washed with brine, dried (MgSO4) and evaporated to give 4-chloro-7-(2-methoxyethoxy)quinazoline (345 mg, 80%).

Workup

  1. extractionwas extracted with ethyl acetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried (MgSO4)
  4. customevaporated

Sources & evidence

ORD record
ord-3a58306be21c45cb9eb7bbe5b3368abf
Source dataset
uspto-grants-2007_08
Patent number
US07262201B1

Reaction notes

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