反应详情

A cold solution (0° C.) of 4-bromobenzonitrile (1 g, 5.5 mmol) in ethanol (25 mL) was saturated with dry HCl(g). The mixture was then stirred at room temperature for 18 hours, after which FT-IR showed complete disappearance of the nitrile. The solution was concentrated to dryness, and further dried in vacuo. The ethyl 4-bromobenzimidate hydrochloride thus obtained was used in the synthesis of compounds 145, 146, 150, and 151.

1. concentrationThe solution was concentrated to dryness
2. customfurther dried in vacuo