反应详情

m-Chloroperbenzoic acid (22.7 g, 92 mmol) was gradually added to a solution of 3-methoxymethoxy-2-methyl-1-propene (9.7 g, 84 mmol) prepared in Reference Example 176 in methylene chloride (200 ml) while cooling in an ice-bath and the mixture was stirred at room temperature for 6 hours. Sodium hydrogencarbonate (14.1 g, 168 mmol), water and methylene chloride were added to the reaction mixture, which was stirred for a while. The organic layer was separated, washed with sodium hydrogencarbonate aqueous solution, sodium thiosulfate aqueous solution and then sodium hydrogencarbonate aqueous solution, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure to afford 2-methoxymethoxymethyl-2-methyloxirane (6.8 g, yield 62%) as a green-colored oil.

1. temperaturewhile cooling in an ice-bath
2. stirringwas stirred for a while
3. customThe organic layer was separated
4. washwashed with sodium hydrogencarbonate aqueous solution, sodium thiosulfate aqueous solution
5. dry with materialsodium hydrogencarbonate aqueous solution, and dried over magnesium sulfate
6. filtrationAfter filtration
7. concentrationthe filtrate was concentrated under reduced pressure