反应详情

A mixture of 4-(4-trifluoromethylphenoxy) piperidine (0.6 g, 2.45 mmol), triphosgene (0.25 g, 0.86 mmol), and pyridine (0.4 ml, 4.90 mmol) in toluene (6 ml) was heated under reflux for 2.5 hours. To which ethyl acetate was added, and the mixture was washed with 10% hydrochloric acid, dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure to afford 4-(4-trifluoromethylphenoxy)piperidine-1-carbonylchloride (0.72 g, yield 96%) as a pale yellow oil.

1. temperaturewas heated
2. temperatureunder reflux for 2.5 hours
3. washthe mixture was washed with 10% hydrochloric acid
4. dry with materialdried over magnesium sulfate
5. filtrationAfter filtration
6. concentrationthe filtrate was concentrated under reduced pressure