反应详情

A mixture of (4-trifluoromethylphenylamino)-piperidine (1.14 g, 4.67 mmol), triphosgene (0.55 g, 1.87 mmol), and triethylamine (0.98 ml, 7.01 mmol) in methylene chloride (10 ml) was stirred at room temperature for 1.5 hours. The reaction mixture was washed with water, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure to afford 4-(4-trifluoromethylphenylamino)piperidine-1-carbonylchloride (1.43 g, quantitative) as a pale yellow oil.

1. washThe reaction mixture was washed with water
2. dry with materialdried over magnesium sulfate
3. filtrationAfter filtration
4. concentrationthe filtrate was concentrated under reduced pressure