Iodoethane → HCID 22938543, compound

HRID 856651Notes

Reaction equation

HRID 856651 reaction equation
[OH:1][CH2:2][C:3]1[N:7]([CH2:8][CH:9]([CH3:11])[CH3:10])[C:6]([SH:12])=[N:5][N:4]=1.I[CH2:14][CH3:15].C(N(CC)CC)C>C(O)C>[CH2:14]([S:12][C:6]1[N:7]([CH2:8][CH:9]([CH3:10])[CH3:11])[C:3]([CH2:2][OH:1])=[N:4][N:5]=1)[CH3:15]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 8471TriethylamineHCID 178448730HCID 178448730, compound

Product 1

HCID 22938543HCID 22938543, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3-hydroxymethyl-4-isobutyl-5-mercapto-4H-1,2,4-triazole (1.0 g), iodoethane (1.0 g) and triethylamine (1.1 ml) in ethanol (10 ml) was stirred for 2 days at 70° C. The solvent was removed under reduced pressure, and the obtained residue was purified by column chromatography (ethanol:ethyl acetate 1:9→1:5), to give 5-ethylthio-3-hydroxymethyl-4-isobutyl-4H-1,2,4-triazole (1.0 g) as pale yellow oil.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe obtained residue was purified by column chromatography (ethanol:ethyl acetate 1:9→1:5)

Sources & evidence

ORD record
ord-a54082a527014b62b6381cdec29b5108
Source dataset
uspto-grants-2007_08
Patent number
US07262185B2

Reaction notes

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