反应详情

A mixture of 4.5 g (0.0233 mole) of 7-hydroxy-6-methoxy-1-tetralone, 5.4 g (0.032 mole) of benzyl bromide and 10 g (0.072 mole) of K2CO3 in 150 ml of acetone was heated to reflux overnight. The reaction as cooled, poured into water and extracted with EtOAc. The EtOAc was dried over Na2SO4 and evaporated to give 7 g of crude product. Crystallization with Et2O gave 4.13 g of product as a white solid, mp 110-111° C.

1. temperaturewas heated
2. temperatureto reflux overnight
3. customThe reaction
4. temperatureas cooled
5. extractionextracted with EtOAc
6. dry with materialThe EtOAc was dried over Na2SO4
7. customevaporated
8. customto give 7 g of crude product
9. customCrystallization with Et2O