反应详情

温度

60 °C

A mixture of 2.87 g (15 mmol) A1, 2.76 g (16.5 mmol) ethyl bromoacetate and 2.90 g (21 mmol) potassium carbonate in 50 ml dry acetone were stirred for 3 h at 60° C. After filtration and removal of the solvent the residue was purified by column chromatography on Silica (ethyl acetate/methanol 100:2). Yield: 3.5.5 g (86 %) A2, colorless solid.

1. filtrationAfter filtration and removal of the solvent the residue
2. customwas purified by column chromatography on Silica (ethyl acetate/methanol 100:2)