Hydroxylamine → HCID 178510916, compound

HRID 856976Notes

Reaction equation

HRID 856976 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]#[N:11])=[CH:4][CH:3]=1.[OH:12][NH2:13]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]=[CH:9][C:10]([NH:13][OH:12])=[NH:11])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 342433-(4-Chlorophenyl)prop-2-enenitrile

Product 1

HCID 178510916HCID 178510916, compoundYield 51%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3-(4-chloro-phenyl)-acrylonitrile (1.63 g, 10 mmol) and hydroxyamine (0.74 ml, 12 mmol) in ethanol (10 ml) was stirred at room temperature overnight. The solvent was evaporated, and the residue was purified by column chromatography (EtOAc: Hexane=1:3) to give 1.0 g (51%) of 3-(4-chloro-phenyl)-N-hydroxy-acrylamidine.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was purified by column chromatography (EtOAc: Hexane=1:3)

Sources & evidence

ORD record
ord-578bb4b3afc24da18386fd60f07449a6
Source dataset
uspto-grants-2006_12
Patent number
US07144876B2

Reaction notes

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