Trifluoroacetic anhydride → HCID 21866554, compound

HRID 857079Notes

Reaction equation

HRID 857079 reaction equation
[NH2:1][CH2:2][C:3]1[S:7][C:6]([C:8]#[N:9])=[C:5](C)[CH:4]=1.[Cl:11]C1C=CSC=1C#N.[Cl:19]C1C=CSC=1C(N)=O.FC(F)(F)C(OC(=O)C(F)(F)F)=O>>[ClH:11].[NH2:1][CH2:2][C:3]1[S:7][C:6]([C:8]#[N:9])=[C:5]([Cl:19])[CH:4]=1

Participants

5

Reactant 4

HCID 9845Trifluoroacetic anhydrideHCID 27574383-Chloro-2-cyanothiopheneHCID 28080883-chlorothiophene-2-carboxamideHCID 218664655-(Aminomethyl)-3-methyl-2-thiophenecarbonitrile

Product 1

HCID 21866554HCID 21866554, compound

Procedure

This compound was prepared in analogy to 5-aminomethyl-3-methylthiophene-2-carbonitrile, preparing the 3-chloro-2-cyanothiophene used by dehydration of 3-chlorothiophene-2-carboxamide with trifluoroacetic anhydride.

Sources & evidence

ORD record
ord-3f5fdab5cee848afbd7f4309327dd089
Source dataset
uspto-grants-2006_12
Patent number
US07144902B1

Reaction notes

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