反应详情

温度

0 °C

tert-Butyl 5-[4-(4-cyanophenyl)-4-(3,4-dimethoxyphenoxy)butyl]hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (0.9 g, 1.7 mmol; from step (d) above) was dissolved in ethyl acetate (25 mL). The solution was cooled to 0° C. Ethyl acetate (25 mL) saturated with gaseous HCl was added and the mixture was stirred at rt for 4 h. The mixture was evaporated and then dissolved in CH3CN. K2CO3 (1 g) and water (0.05 mL) were added and the mixture was stirred for 2 h. The salts were filtered of and the solvent was evaporated, giving 0.71 g (100%) of the title compound.

1. customThe mixture was evaporated
2. dissolutiondissolved in CH3CN
3. additionK2CO3 (1 g) and water (0.05 mL) were added
4. stirringthe mixture was stirred for 2 h
5. filtrationThe salts were filtered of and the solvent
6. customwas evaporated