Hydrochloric Acid → 3-[(1-propylbutyl)sulfonyl]alanine HCl salt

HRID 857265Notes

Reaction equation

HRID 857265 reaction equation
C([NH:4][C@H:5]([C:17]([O:19]C)=[O:18])[CH2:6][S:7]([CH:10]([CH2:14][CH2:15][CH3:16])[CH2:11][CH2:12][CH3:13])(=[O:9])=[O:8])(=O)C.[ClH:21]>C(O)(=O)C>[ClH:21].[CH2:11]([CH:10]([S:7]([CH2:6][C@@H:5]([C:17]([OH:19])=[O:18])[NH2:4])(=[O:8])=[O:9])[CH2:14][CH2:15][CH3:16])[CH2:12][CH3:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86589164methyl N-acetyl-3-[(1-propylbutyl)sulfonyl]alaninate

Product 1

HCID 865891653-[(1-propylbutyl)sulfonyl]alanine HCl salt

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Methyl N-acetyl-3-[(1-propylbutyl)sulfonyl]alaninate (LXXXII, 9.2 g) in acetic acid (50 ml) and concentrated hydrochloric acid (50 ml). The mixture is refluxed for 4 hours then concentrated under reduced pressure. The residue is chased with toluene (2×) then vacuum dried overnight to give 3-[(1-propylbutyl)sulfonyl]alanine hydrochloride salt (LXXXIII).

Workup

  1. temperatureThe mixture is refluxed for 4 hours
  2. concentrationthen concentrated under reduced pressure
  3. customvacuum dried overnight

Sources & evidence

ORD record
ord-2f5174ef05fb455c97f49d434e146a57
Source dataset
uspto-grants-2006_12
Patent number
US07144897B2

Reaction notes

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