反应详情

Methyl N-acetyl-3-[(1-propylbutyl)sulfonyl]alaninate (LXXXII, 9.2 g) in acetic acid (50 ml) and concentrated hydrochloric acid (50 ml). The mixture is refluxed for 4 hours then concentrated under reduced pressure. The residue is chased with toluene (2×) then vacuum dried overnight to give 3-[(1-propylbutyl)sulfonyl]alanine hydrochloride salt (LXXXIII).

1. temperatureThe mixture is refluxed for 4 hours
2. concentrationthen concentrated under reduced pressure
3. customvacuum dried overnight