Hydrochloric Acid → HCID 68610371, compound

HRID 857268Notes

Reaction equation

HRID 857268 reaction equation
C(OC([N:8]([CH2:48][C:49]1[CH:54]=[CH:53][CH:52]=[C:51]([CH2:55][CH3:56])[CH:50]=1)[CH2:9][C@@H:10]([OH:47])[C@@H:11]([NH:21][C:22](=[O:46])[CH:23]([CH2:35][S:36]([CH:39]([CH2:43][CH2:44][CH3:45])[CH2:40][CH2:41][CH3:42])(=[O:38])=[O:37])[NH:24][C:25](=[O:34])[C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=1)[CH2:12][C:13]1[CH:18]=[C:17]([F:19])[CH:16]=[C:15]([F:20])[CH:14]=1)=O)(C)(C)C.[ClH:57]>O1CCOCC1>[ClH:57].[F:20][C:15]1[CH:14]=[C:13]([CH:18]=[C:17]([F:19])[CH:16]=1)[CH2:12][C@H:11]([NH:21][C:22](=[O:46])[CH:23]([CH2:35][S:36]([CH:39]([CH2:43][CH2:44][CH3:45])[CH2:40][CH2:41][CH3:42])(=[O:37])=[O:38])[NH:24][C:25](=[O:34])[C:26]1[CH:27]=[CH:28][C:29]([O:32][CH3:33])=[CH:30][CH:31]=1)[C@H:10]([OH:47])[CH2:9][NH:8][CH2:48][C:49]1[CH:54]=[CH:53][CH:52]=[C:51]([CH2:55][CH3:56])[CH:50]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69135987HCID 69135987, compound

Product 1

HCID 68610371HCID 68610371, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

N1-{(1S,2R)-N-[(t-butyloxy)carbonyl]-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)-amino]-2-hydroxypropyl}-N2-(4-methoxybenzoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide, (LXXXVIII, 114 mg, 0.14 mmole) in hydrochloric acid (4 N, 1 ml) in dioxane. After stirring for 10 minutes at 20–25°, the solvent is removed under reduced pressure to give N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(4-methoxybenzoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide hydrochloride,

Workup

  1. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-98d29ac8512a4eeebc79c618c60eaf0b
Source dataset
uspto-grants-2006_12
Patent number
US07144897B2

Reaction notes

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