Dichloromethane → HCID 10290130, compound

HRID 857298Notes

Reaction equation

HRID 857298 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[C:22]([C:30]([S:33]([CH3:36])(=[O:35])=[O:34])([CH3:32])[CH3:31])[CH:23]=[C:24]3[C:29]=2[N:28]=[CH:27][CH:26]=[CH:25]3)=[CH:16][C:3]=1[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([CH3:15])(=[O:14])=[O:13])=[CH:8][CH:7]=1.C(Cl)Cl.CCO[C:43]([CH3:45])=[O:44]>>[F:1][C:2]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[C:22]([C:30]([S:33]([CH3:36])(=[O:34])=[O:35])([CH3:32])[CH3:31])[CH:23]=[C:24]3[C:29]=2[N:28]=[CH:27][CH:26]=[CH:25]3)=[CH:16][C:3]=1[CH2:4][N:5]([C:6]1[CH:7]=[CH:8][C:9]([S:12]([CH3:15])(=[O:13])=[O:14])=[CH:10][CH:11]=1)[C:43](=[O:44])[C:45]1[CH:18]=[CH:19][CH:2]=[CH:3][CH:4]=1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 21865639HCID 21865639, compound

Product 1

HCID 10290130HCID 10290130, compound

Procedure

Prepared in two steps according to the procedures described in EXAMPLE 44 (Steps 2 and 3) but using {2-fluoro-5-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-benzyl}-(4-methanesulfonyl-phenyl)-amine from EXAMPLE 61 (Step 4) as the starting material. Flash chromatography (CH2Cl2:EtOAc; 3:7) afforded the title compound as a foam.

Workup

  1. customPrepared in two steps

Sources & evidence

ORD record
ord-56fa211c839a4cbda236be05b8ca8acf
Source dataset
uspto-grants-2006_12
Patent number
US07144896B2

Reaction notes

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