Hydrochloric Acid → HCID 69656116, compound

HRID 857788Notes

Reaction equation

Cl.C(OC([NH:9][C@H:10]([CH:35]1[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1)[C:11]([N:13]1[CH2:34][CH2:33][CH2:32][C@H:14]1[C:15]([NH:17][CH2:18][C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=1[C:26]1[C:30]([Cl:31])=[N:29][S:28][N:27]=1)=[O:16])=[O:12])=O)(C)(C)C>>[ClH:25].[NH2:9][C@H:10]([CH:35]1[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1)[C:11]([N:13]1[CH2:34][CH2:33][CH2:32][C@H:14]1[C:15]([NH:17][CH2:18][C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=1[C:26]1[C:30]([Cl:31])=[N:29][S:28][N:27]=1)=[O:16])=[O:12]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 69656109HCID 69656109, compound

Product 1

HCID 69656116HCID 69656116, compound

Procedure

HCl gas was bubbled through a stirred 0° C. solution of 1-{(2R)-2-[(tert-butoxycarbonyl)amino]-2-cyclohexylethanoyl}-N-[5-chloro-2-(4-chloro-1,2,5-thiadiazol-3-yl)benzyl]-L-prolinamide (41.1 mg, 0.07 mmol) CH2Cl2 (1.0 mL) for 15 min. The solution was reduced in vacuo. 1-[(2R)-2-amino-2-cyclohexylethanoyl]-N-[5-chloro-2-(4-chloro-1,2,5-thiadiazol-3-yl)benzyl]-L-prolinamide hydrochloride was isolated as a solid. LCMS m/z=496.5.

Sources & evidence

ORD record: ord-77d986982ae34bfab333d226faedbc89
Source dataset: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07144899B2

Reaction notes

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