Ammonium Hydroxide → HCID 178508000, compound

HRID 858011Notes

Reaction equation

HRID 858011 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[OH:14])=[N:11][CH:10]=[CH:9][CH:8]=2)([O-])=O.[OH-].[NH4+]>[Pt].CO>[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[OH:14])=[N:11][CH:10]=[CH:9][CH:8]=2

Participants

5

Reactant 2

HCID 14923Ammonium HydroxideHCID 178526774HCID 178526774, compound

Product 1

HCID 178508000HCID 178508000, compoundYield 96.5%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

A mixture containing 3-nitro[1,5]naphthyridin-4-ol (7.5 g), methanol (200 mL), ammonium hydroxide (50 mL) and 5% platinum on carbon (0.75 g) was placed on a Parr apparatus for 6 hours. The reaction mixture was filtered to remove catalyst and then filtered a second time using Celite® filter aid. The filtrate was concentrated under vacuum to provide 6.1 g of 3-amino[1,5]naphthyridin-4-ol as a brown solid.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customto remove catalyst
  3. filtrationfiltered a second time
  4. filtrationfilter aid
  5. concentrationThe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-392a1ab810574c67939c6c33579fea39
Source dataset
uspto-grants-2006_12
Patent number
US07148232B2

Reaction notes

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